Primary lymphoma of the brain is cancer of the lymph cells that starts in the brain.

The cause of primary brain lymphoma is unknown. It is more common in people ages 45 - 70.

Patients who have a weakened immune system are at greater risk for primary lymphoma of the brain. Common causes of a weakened immune system include:

• HIV
• Organ transplants (especially heart transplants)

Lymphoma is also linked to Epstein-Barr Virus (EBV) infection, the virus that causes mononucleosis.

The incidence of primary brain lymphoma is rising, but it is still relatively rare.

• Changes in speech
• Changes in vision
• Confusion
• Fever
• Hallucinations
• Headaches
• Numbness to hot, cold, and pain
• Personality changes
• Seizures
• Weakness in hands
• Weight loss

The following tests may be performed to help diagnose a primary lymphoma of the brain:

• Biopsy of the brain
• CSF cell count
• CSF total protein
• Head CT scan or MRI

The condition is usually first treated with corticosteroids. However, chemotherapy may increase survival by 3 - 4 years, or longer. The chemotherapy is usually high doses of methotrexate given through a vein (intravenously) or a spinal tap.

Treating patients with weakened immune systems is not as successful, but it is improving.

Radiation therapy used to be the main treatment for primary lymphoma of the brain. Now it is usually reserved for treating patients who do not respond to chemotherapy.

Treatment with multiple therapies (combination therapy) is common.

The survival of untreated primary brain lymphoma is under 2 months. Treated with chemotherapy, patients often survive 3-4 years or more. About 40% of patients are alive at 5 years. In general, older patients have a worse outlook than younger patients.

Possible complications include:

• Chemotherapy side effects, including low blood counts
• Radiation side effects, including confusion, headaches, nervous system (neurologic) problems, and tissue death
• Return (recurrence) of the lymphoma

DeAngelis LM. Tumors of the central nervous system and intracranial hypertension and hypotension. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 199.

National Cancer Institute. Primary CNS lymphoma treatment (PDQ). 2009. Accessed February 25, 2009.